Oriented attachment of VNAR proteins, via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance
نویسندگان
چکیده
منابع مشابه
Site‐Selective Modification of Proteins with Oxetanes
Oxetanes are four-membered ring oxygen heterocycles that are advantageously used in medicinal chemistry as modulators of physicochemical properties of small molecules. Herein, we present a simple method for the incorporation of oxetanes into proteins through chemoselective alkylation of cysteine. We demonstrate a broad substrate scope by reacting proteins used as apoptotic markers and in drug f...
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Shape- and size-controlled syntheses of metal nanoparticles have been achieved by galvanic displacement reaction between an aqueous solution of metal salt and Cu foil substrate. In particular, cubic and spheric nanoparticles of Pt (Au) with a fairly narrow size distribution were produced by reacting K(2)PtCl(4) (HAuCl(4)) with a Cu foil in an aqueous medium with and without CuCl(2) under differ...
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For a reaction to be generally useful for protein modification, it must be site-selective and efficient under conditions compatible with proteins: aqueous media, low to ambient temperature, and at or near neutral pH. To engineer a reaction that satisfies these conditions is not a simple task. Olefin metathesis is one of most useful reactions for carbon-carbon bond formation, but does it fit the...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2019
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c9cc02655j